University of Oxford
Professor Patrik Rorsman is a Professor of Diabetic Medicine at the Oxford Centre for Diabetes, Endocrinology & Metabolism and a Medical Tutor of Harris Manchester College.
Medicine / Diabetes
Cell and Molecular Biology - the aim of our research is to explain how changes in the plasma glucose concentration via islet cell electrical activity and increases in the cytoplasmic Ca2+-concentration regulate exocytotic release of insulin as well as glucagon and somatostatin. Our work involves a combination of techniques to study secretion at the molecular, cellular and systemic levels. This requires sophisticated methodology to record the minute electrical currents flowing across biological membranes and secretion in individual cells at millisecond resolution. We also use optical techniques that allow us to monitor the movements of single secretory granules within the cell prior and during secretion.
These studies will promote our understanding of the fundamental processes that control insulin secretion under physiological conditions and determine the defects associated with clinical diabetes. Ultimately, our studies will allow the development of new diabetes therapies by identifying novel drug targets.
Patrik is a Medical Tutor at Harris Manchester College
Oxford Centre for Diabetes and Endocrine Medicine http://www.ocdem.ox.ac.uk
Link to books and publications in peer-review journals