Dr Gina Hadley

Research Fellow

Gina Hadley is a Research Fellow at Harris Manchester College and at the Acute Stroke Programme, Radcliffe Department of Medicine. She is also a clinical doctor in Oxford and Banbury. Gina originally started her career in Industry with a Pharmacology degree at Edinburgh, spending a year at Queen’s University in Canada. Though (and still) fascinated by science she always had a burning desire to read medicine and was a Graduate Entry student, here at Harris Manchester College. Upon graduation she embarked upon an academic foundation programme followed by an academic clinical fellowship. She attained a Masters in Evidence-Based Medicine and has just completed her PhD in novel stroke therapies.


Gina is one of the tutors in Clinical Medicine at Harris Manchester College and a lecturer on the Graduate Entry Medical Course, Oxford, trained in the examination of medical students. She tutors first year graduate medics in critical appraisal in addition to providing bedside teaching and preparation for examinations.


Gina’s main research interest is novel endogenous neuroprotection – looking at neurons in the brain that are resistant to oxygen and glucose starvation and asking why they survive. Answering this question may help to protect vulnerable neurons that die following stroke.

Selected publications

Sutherland, B.A., Neuhaus, A.A., Couch, Y., Balami, J.S., DeLuca, G.C., Hadley. G., Harris, S.L., Grey, A.N. and Buchan AM. (2016). The transient intraluminal filament middle cerebral artery occlusion model as a model of endovascular thrombectomy in stroke. J Cereb Blood Flow Metab. 36(2):363-9.

Balami, J.S., Sutherland, B.A., Edmunds, L.D., Grunwald, I.Q., Neuhaus, A.A., Hadley, G., Karbalai, H., Metcalf, K.A., DeLuca, G.C. and Buchan, A.M. (2015). A systematic review and meta-analysis of randomized controlled trials of endovascular thrombectomy compared with best medical treatment for acute ischemic stroke. Int J Stroke 10(8):1168-78.

Visser C, Hadley G, Wee B. Reality of evidence-based practice in palliative care. Cancer Biol Med. 2015 Sep;12(3):193-200. doi: 10.7497/j.issn.2095-3941.2015.0041 

Neuhaus AA, Rabie T, Sutherland BA, Papadakis M, Hadley G, Cai R, Buchan AM. Importance of preclinical research in the development of neuroprotective strategies for ischemic stroke. JAMA Neurol. 2014 May;71(5):634-9. Review.

Hadley G, Derry S, Moore RA, Wiffen PJ. Transdermal fentanyl for cancer pain. Cochrane Database Syst Rev. 2013 Oct 5;10:CD010270.

Balami JS, Hadley G, Sutherland BA, Karbalai H, Buchan AM. The exact science of stroke thrombolysis and the quiet art of patient selection. Brain. 2013 Dec;136(Pt 12):3528-53.

Hadley G, De Luca GC, Papadakis M, Buchan AM. Endogenous neuroprotection: Hamartin modulates an austere approach to staying alive in a recession. Int J Stroke. 2013 Aug;8(6):449-50.

Papadakis M, Hadley G, Xilouri M, Hoyte LC, Nagel S, McMenamin MM, Tsaknakis G, Watt SM, Drakesmith CW, Chen R, Wood MJ, Zhao Z, Kessler B, Vekrellis K, Buchan AM. Tsc1 (hamartin) confers neuroprotection against ischemia by inducing autophagy. Nat Med. 2013 Mar;19(3):351-7

Nagel S, Hadley G, Pfleger K, Grond-Ginsbach C, Buchan AM, Wagner S, Papadakis M. Suppression of the inflammatory response by diphenyleneiodonium after transient focal cerebral ischemia. J Neurochem. 2012 Nov;123 Suppl 2:98-107.

Hadley, G, Derry, S, Moore, R. & Wee, B (2009). ‘Can Observational Studies Provide a Realistic Alternative to Randomized Controlled Trials in Palliative Care?’ Journal Of Pain & Palliative Care Pharmacotherapy,23:2,106-113

Contact Details
Postal Address
Harris Manchester College
Mansfield Road
United Kingdom