Dr Gina Hadley

Research Fellow

Gina Hadley BSc (Hons), BMBCh, MRCP (2010), MSc (Oxon.), DPhil 

Associate Medical Tutor Harris Manchester College 

Honorary Clinical Lecturer in Neurology 

American Academy of Neurology Medical Education Research Fellow. 


Dr Gina Hadley has been a Clinical Tutor at Harris Manchester College since 2008 and Associate Medical Tutor with responsibility for Medical Students at the College since 2017. She is an Honorary Clinical Lecturer in Neurology and currently undertaking an American Academy of Neurology Medical Education Research Fellowship at the University of Oxford.  

Dr Hadley started her career in Pharmacology, gaining a first class honours degree from the University of Edinburgh. This included a year on exchange to Queen’s University in Canada, taking courses predominantly in neuropharmacology and neuroanatomy stimulating an interest in neurodegeneration and its lack of treatment options. Following a year of working and volunteering in healthcare systems in the UK, Australia and Paraguay, she studied medicine on the Graduate Entry Programme at Oxford. During her time as a student she published systematic reviews with the Pain Research Unit and gained Wellcome Funding for her elective at the Kenya Medical Research Institute (KEMRI). She began her Clinical training on the Academic Foundation Programme in Oxford, working for Professor Alastair Buchan looking at neuroprotection in stroke. During her Academic Clinical Fellowship she was second author on a Nature Medicine paper describing hamartin as a novel endogenous neuroprotectant. This led to a DPhil in endogenous neuroprotection. She also completed a Masters in Evidence Based Healthcare resulting in a Cochrane Review of Transdermal Fentanyl in Cancer Pain. She is currently a Specialty Registrar in Geriatrics and Acute General Medicine in the Oxford Deanery.  

Medical Education 

Dr Hadley has over 10 years’ experience teaching at a University level. She has lectured on both Graduate Entry Courses and for the Clinical School. She is currently the American Academy of Neurology Medical Education Fellow – the first time this Fellowship has been awarded outside of the United States. She is developing a programme called ‘Expert Patient Tutors’ (EPTs) on the 5th Year Clinical Neurosciences Course at Oxford Medical School. This involves stable patients with neurological disorders such as Parkinson’s disease or Multiple Sclerosis teaching medical students communication and examination skills.  This will result in the development of a Toolkit to extend the role of EPTs to other hospital specialities and General Practice and to the community. The EPT Program will be piloted at Stanford University in April 2018 to ensure its applicability to North American Medical Education. 

Another initiative Dr Hadley is involved in is ‘Looking, Seeing and Understanding Neurology: Developing medical skills in a non-clinical environment’. This lecture teaches an approach neurological diseases in a creative way to help consolidate key concepts relevant to core curriculum using artists that both possess and depict neuropathology. It also introduces an afternoon session available during every rotation at the Ashmolean Museum in collaboration with Dr Jim Harris. The ultimate aim is to dispel myths, confirm beliefs and combat neurophobia through art. 

Recent Awards: 

2017: American Academy of Neurology Medical Education Research Fellowship 

2016: World Stroke Organisation Brief Clinical Exchange Scholarship – The Calgary Stroke Program, June 2017 to observe the thrombectomy service. 

Recent Publications: 

Hadley G, Neuhaus AA, Couch Y, Beard DJ, Adriaanse BA, Vekrellis K, DeLuca GC, Papadakis M, Sutherland BA, Buchan AM. The role of the endoplasmic reticulum stress response following cerebral ischemia. Int J Stroke. 2017 Jan 1:1747493017724584. doi: 10.1177/1747493017724584. [Epub ahead of print] 

Neuhaus AA, Couch Y, Hadley G, Buchan AM.  Neuroprotection in stroke: the importance of collaboration and reproducibility. Brain. 2017 Jun 20. doi: 10.1093/brain/awx126. [Epub ahead of print] 

Sutherland, B.A., Neuhaus, A.A., Couch, Y., Balami, J.S., DeLuca, G.C., Hadley. G., Harris, S.L., Grey, A.N. and Buchan AM. (2016). The transient intraluminal filament middle cerebral artery occlusion model as a model of endovascular thrombectomy in stroke. Cereb Blood Flow Metab. 36(2):363-9. 

Balami, J.S., Sutherland, B.A., Edmunds, L.D., Grunwald, I.Q., Neuhaus, A.A., Hadley, G., Karbalai, H., Metcalf, K.A., DeLuca, G.C. and Buchan, A.M. (2015). A systematic review and meta-analysis of randomized controlled trials of endovascular thrombectomy compared with best medical treatment for acute ischemic stroke. Int J Stroke 10(8):1168-78. 

Neuhaus AA, Rabie T, Sutherland BA, Papadakis M, Hadley G, Cai R, Buchan AM. Importance of preclinical research in the development of neuroprotective strategies for ischemic stroke. JAMA Neurol. 2014 May;71(5):634-9. Review. 

Hadley G, Derry S, Moore RA, Wiffen PJ. Transdermal fentanyl for cancer pain. Cochrane Database Syst Rev. 2013 Oct 5;10:CD010270.  

Balami JS, Hadley G, Sutherland BA, Karbalai H, Buchan AM. The exact science of stroke thrombolysis and the quiet art of patient selection. Brain. 2013 Dec;136(Pt 12):3528-53. doi: 10.1093/brain/awt201. Epub 2013 Sep 14. Review 

Hadley G, De Luca GC, Papadakis M, Buchan AM. Endogenous neuroprotection: Hamartin modulates an austere approach to staying alive in a recession. Int J Stroke. 2013 Aug;8(6):449-50.  

Papadakis M, Hadley G, Xilouri M, Hoyte LC, Nagel S, McMenamin MM, Tsaknakis G, Watt SM, Drakesmith CW, Chen R, Wood MJ, Zhao Z, Kessler B, Vekrellis K, Buchan AM. Tsc1 (hamartin) confers neuroprotection against ischemia by inducing autophagy. Nat Med. 2013 Mar;19(3):351-7 

Nagel S, Hadley G, Pfleger K, Grond-Ginsbach C, Buchan AM, Wagner S, Papadakis M. Suppression of the inflammatory response by diphenyleneiodonium after transient focal cerebral ischemia. J Neurochem. 2012 Nov;123 Suppl 2:98-107.  




Contact Details
Postal Address
Harris Manchester College
Mansfield Road
United Kingdom