Selective oral ROCK2 inhibitor down-regulates IL-21 and IL-17 secretion in human T cells via STAT3-dependent mechanism

Zanin-Zhorov A, Weiss JM, Nyuydzefe MS, Chen W, Scher JU, Mo R, Depoil D, Rao N, Liu B, Wei J, Lucas S, Koslow M
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et al
No abstract available
Keywords:

3101 Biochemistry and Cell Biology

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32 Biomedical and Clinical Sciences

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31 Biological Sciences

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3204 Immunology

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Autoimmune Disease

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Arthritis

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2.1 Biological and endogenous factors

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1.1 Normal biological development and functioning

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Inflammatory and immune system

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Administration, Oral

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CD4-Positive T-Lymphocytes

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Cells, Cultured

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Humans

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Interleukin-17

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Interleukins

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Phosphorylation

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Promoter Regions, Genetic

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Protein Kinase Inhibitors

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STAT3 Transcription Factor

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Transcription, Genetic

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rho-Associated Kinases